ToxPanel

ToxPanel performs gene-set analysis to quantify liver and kidney injury by computing activation scores from aggregated gene-set fold-change values of gene expression data.

Key Features:

• Activation Scores Calculation: Computes activation scores by aggregating fold-change values across predefined gene sets to quantify organ injury signals.
• Predefined Gene Sets: Includes predefined gene sets developed to correlate with liver and kidney injury phenotypes.
• Custom Gene Set Analysis: Supports analysis of user-supplied custom gene sets to evaluate their association with injury-related expression changes.

Scientific Applications:

• Toxicological assessment: Enables analysis of gene expression changes associated with toxicological responses in liver and kidney tissues.
• Pathophysiology studies: Supports investigation of pathophysiological changes in liver and kidney by linking expression patterns to injury phenotypes.
• Biomarker and target identification: Facilitates identification of candidate biomarkers and potential therapeutic targets based on contributory genes within gene sets.
• Gene-set validation: Allows validation of custom gene sets for their robustness in representing injury-associated expression signatures.
• Correlation with histopathology: Supports correlating aggregated gene-set activation scores with histopathological injury outcomes.

Methodology:

Activation scores are calculated by aggregating gene-set fold-change values derived from gene expression data.