transeq (EBI)

transeq (EBI) translates nucleotide sequences into peptide sequences to identify potential protein products from nucleotide data.

Key Features:

• Six-frame translation: Translates nucleotide sequences in all six reading frames (three forward and three reverse) to capture all possible coding translations.
• Batch multi-frame output: Supports outputting translations for multiple frames simultaneously for processing multiple sequences or frames.
• EMBL-EBI integration: Operates within the EMBL-EBI search and sequence analysis framework and leverages the EBI Search full-text search engine spanning nearly 5 billion entries.

Scientific Applications:

• Protein function prediction: Provides peptide sequences for downstream motif and domain analysis to infer potential protein functions.
• Genome annotation: Identifies coding regions and predicts corresponding proteins to support genomic research and annotation.
• Viral genomics: Enables translation of viral genomes, including SARS-CoV-2 (COVID-19) sequences, to analyze viral proteins relevant to vaccine and therapeutic research.

Methodology:

Transeq-Ebi employs an algorithmic approach to translate nucleotide sequences accurately across all six reading frames.