TransmiR

TransmiR catalogs experimentally supported transcription factor (TF)–microRNA (miRNA) regulatory relationships to support analysis of transcriptional and posttranscriptional gene regulation.

Key Features:

• Extensive Data Collection: Derived from a manual survey of approximately 5,000 scientific reports, yielding 243 experimentally supported TF–miRNA regulatory relationships reported across 86 publications and involving 82 transcription factors and 100 microRNAs.
• Regulatory Pair Information: Provides detailed TF–miRNA regulatory pair records with literature references and PubMed IDs for traceability to primary sources.
• Organism-Specific Data: Annotates the organism in which each TF–miRNA relationship was observed to enable cross-species comparison.
• Disease and Function Annotations: Includes miRNA function annotations and disease associations, highlighting links to tumorigenesis and other pathologies.

Scientific Applications:

• Mechanistic Studies: Enables exploration of molecular mechanisms by which transcription factors regulate microRNAs.
• Disease Research: Supports identification of regulatory disruptions and candidate biomarkers or therapeutic targets for diseases such as cancer.
• Comparative Genomics: Facilitates comparative analyses across species to study conservation and divergence of TF–miRNA regulatory relationships.

Methodology:

Manual literature curation of approximately 5,000 reports was used to extract experimentally supported TF–miRNA regulatory relationships and annotate each pair with PubMed IDs, organism information, miRNA function, and disease associations.