TranspoScope

TranspoScope visualizes and evaluates potential retrotransposon insertions from targeted and whole-genome sequencing data to present experimental evidence for their genomic locations and impacts on the human genome.

Key Features:

• Visualization of Retrotransposon Insertions: Visualizes evidence from targeted and whole-genome sequencing for retrotransposon insertions, highlighting their genomic locations.
• Evaluation of Insertion Evidence: Presents experimental evidence to support assessment of candidate retrotransposon insertion events.
• Compatibility with MELT and TIPseqHunter: Accepts insertion calls or outputs from MELT and TIPseqHunter as input data sources.

Scientific Applications:

• Genome evolution and stability: Enables analysis of how retrotransposon insertions influence human genome dynamics and stability.
• Genetic diversity and disease mechanisms: Supports investigation of the role of retrotransposons in genetic diversity and disease-related mechanisms.
• Genomic instability and disease associations: Facilitates study of contributions of retrotransposons to genomic instability and potential links to various diseases.
• Development and aging: Aids exploration of retrotransposon impacts during prenatal development, disease progression, and aging processes.

Methodology:

Integrates insertion calls from sequencing experiments, including outputs from MELT and TIPseqHunter, to display sequencing-derived evidence of retrotransposon insertions in genomic context.