TRIP

TRIP catalogs protein–protein interactions involving mammalian transient receptor potential (TRP) channels, which are Ca(2+)-permeable cation channels, to support analysis of TRP-mediated cellular signaling and disease-associated molecular networks.

Key Features:

• Curated PPI dataset: 490 protein–protein interaction pairs between 28 TRP channels and 297 cellular proteins compiled from 277 peer‑reviewed publications.
• Biological scope: Focuses specifically on mammalian TRP channels that transduce diverse stimuli into electrochemical signals.
• Evidence categorization: Organizes interaction data into screening, validation, characterization, and functional consequence categories.
• Experimental metadata: Records analytical methods, gene constructs, and cell/tissue types reported in the source studies.
• Disease relevance: Includes reported associations between TRP channel interactions and neurological disorders, cardiovascular disease, and cancer.

Scientific Applications:

• Molecular network analysis: Enables exploration of molecular interaction networks centered on TRP channels.
• Functional interpretation: Supports assessment of the functional consequences of specific TRP channel PPIs using categorized evidence.
• Disease mechanism investigation: Facilitates study of TRP channel involvement in neurological disorders, cardiovascular disease, and cancer.

Methodology:

Systematic manual curation of PPI information from 277 peer‑reviewed publications with organization of entries into screening, validation, characterization, and functional consequence categories.