TrypInDB

TrypInDB aggregates curated data on small molecule inhibitors targeting Trypanosoma species to support drug-discovery research for trypanosomiasis.

Key Features:

• Extensive Data Collection: Compiles information on more than 14,000 small molecule inhibitors from over 700 published research articles.
• Comprehensive Information Sets: Provides for each inhibitor activity values, sources of inhibitors, enzyme targets, structural data, toxicity profiles, and literature references.
• Advanced Search Capabilities: Supports multi-field filtering, sub-structure searches, and comparisons with FDA-approved drugs for repurposing analyses.
• Data Export Options: Exports queried records and chemical structures in various formats.
• Integration with Related Databases: Integrated with LeishInDB to link inhibitor data across related parasitic-disease datasets.

Scientific Applications:

• Combination Therapy Exploration: Facilitates exploration of combination therapies to overcome drug resistance in Trypanosoma species.
• Drug Repurposing and Redesign: Enables repurposing or redesign of existing inhibitors to develop new therapeutic agents with reduced toxicity.
• Novel Therapeutics Discovery: Supports investigation of novel therapeutics through data-driven approaches.

Methodology:

Compilation of inhibitor data from over 700 published research articles; support for sub-structure searches and comparisons with FDA-approved drugs; export of records and structures in various formats; integration with LeishInDB.