TTD

TTD provides comprehensive curated data on therapeutic targets, their regulators, target‑interacting proteins, and associated patented agents to support target‑centric drug discovery and translational research.

Key Features:

• Target regulators: Includes detailed data on target‑regulating microRNAs and transcription factors to describe regulatory mechanisms influencing therapeutic targets.
• Target‑interacting proteins: Records proteins that interact with therapeutic targets to expand the view of potential interaction networks.
• Patented therapeutic agents: Contains information on patented agents including molecular structures and experimental activity values where available.
• Regulatory mechanisms and biochemical classes: Annotates targets with regulatory mechanisms and biochemical class information.
• ICD‑11 integration: Links therapeutic targets to International Classification of Diseases (ICD‑11) codes for systematic association with clinical conditions.
• Comprehensive target sets: Maintains updated sets of targets reported in the literature and targets successful in clinical trials.

Scientific Applications:

• Systems pharmacology: Supports systems pharmacology analyses by providing target, regulator, and interaction data for network‑level studies.
• Molecular landscape analysis: Enables molecular landscape analyses through aggregated target, regulatory, and biochemical class annotations.
• Drug discovery tool development: Serves as a data source for developing and validating computational drug discovery and target‑prioritization methods.

Methodology:

Computational methods and database compilation procedures are not specified in the provided description.