TuberQ

TuberQ provides druggability analyses of Mycobacterium tuberculosis (Mtb) proteins to support selection and prioritization of targets for structure-based drug design and screening campaigns.

Key Features:

• Druggability Analysis: Provides consistent druggability analysis of Mtb proteins to aid identification and selection of potential drug targets for screening campaigns and structure-based drug design.
• Structural Druggability Assessment: Performs structural druggability analyses on all available unique Mtb structures and high-quality structural homology-based models, evaluating putative inhibitor binding pockets and integrating results with protein functional and biological data.
• Gene Essentiality Data: Includes gene essentiality information derived from whole-cell-based knockout experiments to identify genes vital for Mtb survival.
• Expression Information: Provides expression data from microarray experiments conducted under various stress-related conditions to inform protein functional roles and their potential impact on druggability.

Scientific Applications:

• Target Identification: Integrates structural, functional, and biological data to facilitate identification of novel putative Mtb drug targets.
• Structure-based Drug Design and Prioritization: Supports selection and prioritization of protein targets for structure-based drug design and screening efforts.

Methodology:

Performs structural druggability analyses on available Mtb structures and homology-based models, evaluates putative inhibitor binding pockets, and combines these structural assessments with functional and biological data.