tumorhope

tumorhope catalogs experimentally validated tumor homing peptides and their annotations to support characterization and design of peptide-based tumor targeting and tumor-associated vasculature targeting.

Key Features:

• Curated entries: 744 experimentally validated peptides compiled from published scientific papers, patents, and existing databases.
• Sequence and target annotations: Each entry includes amino acid sequence, target tumor type, target cell, identification techniques, and receptor interactions.
• Derived structural and physicochemical data: Annotations include secondary and tertiary structure information, amino acid composition, and computed physicochemical properties such as charge, polarity, and hydrophobicity.
• Common motifs identification: Annotation of motifs including RGD (Arg-Gly-Asp) and NGR (Asn-Gly-Arg) associated with tumor angiogenic markers.
• Target diversity: Peptides target a range of tumors, including breast, lung, prostate, melanoma, and colon cancers.

Scientific Applications:

• Peptide-based drug and delivery design: Use of validated peptide sequences and annotations to develop targeted therapeutics and delivery systems.
• Targeted therapy development: Leverage receptor interaction and targeting data to design therapies that minimize off-target effects.
• Cross-tumor comparative analysis: Enable comparison of peptide targeting behaviors across tumor types such as breast, lung, prostate, melanoma, and colon.
• Peptide engineering and optimization: Inform design and modification of peptides using amino acid composition, structural annotations, and physicochemical profiles.

Methodology:

Data were curated from published scientific papers, patents, and existing databases; each peptide entry was annotated with amino acid sequence, target tumor type, target cell, identification techniques, and receptor interactions; derived annotations include secondary and tertiary structures, amino acid composition, computed physicochemical properties (charge, polarity, hydrophobicity), and identification of motifs such as RGD and NGR.