TUPDB

TUPDB catalogs target-unrelated peptides (TUPs) to support interpretation and filtering of phage display selection (biopanning) results.

Key Features:

• Curated TUP collection: Contains 73 experimentally confirmed TUPs and 1963 potential TUPs.
• Data sources: Aggregates entries from TUPScan, the BDB database, and public research articles.
• Manual curation: Entries are manually curated to enhance data accuracy and reliability.
• Integration with TUPScan: Linked with TUPScan to facilitate detailed analysis and detection of TUPs.
• TUP identification and removal: Provides data and functionality to identify and eliminate target-unrelated peptides from phage display datasets.

Scientific Applications:

• Phage display analysis: Improves interpretation of biopanning results by distinguishing true binders from TUPs.
• Epitope mapping: Enhances epitope mapping quality by removing confounding TUPs from datasets.
• Vaccine development: Supports selection of genuine target-binding peptides for vaccine antigen discovery.
• Diagnostics: Aids identification of specific peptide biomarkers by excluding nonspecific TUPs.
• Therapeutics discovery: Assists therapeutic peptide discovery by filtering out target-unrelated sequences.

Methodology:

Entries were aggregated from TUPScan, the BDB database, and public research articles and manually curated; the database integrates with TUPScan to enable detailed analysis and identification/removal of TUPs.