TWCOM

TWCOM implements a Tweedie distribution-based model for inferring cell-cell communication in spatially resolved transcriptomics data.

Key Features:

• Tweedie distribution-based model: The model operates under a generalized additive model framework for accurate cell-cell communication inference.
• Data type compatibility: Handles both single-cell resolution and spot-based spatially resolved transcriptomics data.

Scientific Applications:

• Cell-cell communication inference: Unveils intricate cellular behaviors at the molecular level to understand complex biological processes.
• Pathological analysis: Informs targeted interventions in various pathological contexts through spatial transcriptomics analysis.

Methodology:

TWCOM uses a Tweedie distribution-based model implemented under a generalized additive model framework.