UBCG2

UBCG2 reconstructs highly resolved bacterial phylogenomic trees using a refined set of 81 universally single-copy core genes derived from 3,508 genomes across 43 phyla to elucidate evolutionary relationships among bacteria.

Key Features:

• Core Gene Set: Utilizes a refined set of 81 core genes selected from genomes of 3,508 bacterial species across 43 phyla, each universally present in single copy.
• Functional Diversity: Categorizes the gene set into nine Clusters of Orthologous Groups (COGs) functional categories to represent diverse essential biological functions.
• Pipeline Integration: Integrates the core genes into a complete phylogenomic tree reconstruction pipeline for bacterial datasets.

Scientific Applications:

• Phylogenomics: Enables reconstruction of bacterial evolutionary relationships with improved resolution.
• Large-scale genomic analyses: Supports analyses of large-scale bacterial genomic datasets to discern finer evolutionary relationships.
• Cross-disciplinary research: Applicable to studies in microbiology, evolutionary biology, and bioinformatics requiring robust bacterial phylogenies.

Methodology:

Core genes were selected from an extensive collection of bacterial genomes based on universal presence and single-copy status; the pipeline employs these genes to reconstruct phylogenomic trees, leveraging computational techniques to handle large datasets efficiently.