UCSC Interaction Browser

UCSC Interaction Browser visualizes and integrates functional genomics datasets to reveal regulatory interactions and correlative relationships among genes and their products.

Key Features:

• Simultaneous Data Viewing: Displays multiple genomic datasets concurrently, including genome-wide protein-protein and protein-DNA interactions alongside gene expression data.
• Access to Public Datasets: Provides interaction networks and functional genomics datasets from public sources, including datasets relevant to human cancer samples.
• Custom Data Uploads: Supports import of user-supplied datasets or networks for integration and analysis.
• CircleMap Visualization: Implements CircleMap to present multiple 'omics' datasets within the context of curated, predicted, directed, and undirected regulatory interactions.
• Correlative Relationship Navigation: Enables traversal of correlative relationships for specific gene sets mapped to biological pathways.

Scientific Applications:

• Functional Genomics: Integrates diverse high-throughput datasets to elucidate gene function and regulatory network structure.
• Systems Biology: Facilitates analysis of interactions and pathway-level relationships across multi-omics data.
• Cancer Research: Supports examination of regulatory mechanisms and interaction patterns in human cancer samples.

Methodology:

Uses a consensus-based approach to integrate curated and predicted observations about genes and their products.