UcTCRdb

UcTCRdb catalogs 669,900 unconventional T cell receptor (TCR) sequences from 34 studies across humans, mice, and cattle to enable analysis of recognition of non-polymorphic antigen-presenting molecules and public antigen specificities by unconventional T cells.

Key Features:

• Dataset Composition: Contains 669,900 unconventional TCR sequences aggregated from 34 studies spanning human, mouse, and cattle datasets.
• Unconventional TCR Biology: Focuses on TCRs from unconventional T cell subpopulations that recognize non-polymorphic antigen-presenting molecules and exhibit public antigen specificities.
• Sequence Irregularity Handling: Addresses analytical challenges posed by the small size and irregularities of unconventional TCR sequences to support systematic analysis.
• Integrated Analysis Tools: Includes basic and advanced computational tools for TCR sequence analysis and repertoire characterization.

Scientific Applications:

• Unconventional T cell immunity: Enables examination of antigen recognition patterns and effector features of unconventional T cells, including non-MHC interactions.
• Cross-species comparison: Supports comparative analysis of TCR repertoires across humans, mice, and cattle.
• Translational research: Facilitates investigation of immune-response mechanisms relevant to immunotherapy and vaccine development.

Methodology:

Aggregates unconventional TCR sequences from 34 published studies to compile a dataset of 669,900 sequences across human, mouse, and cattle and supplies basic and advanced computational analysis tools.