ukbpheno

ukbpheno generates standardized binary phenotypes from UK Biobank main and record-level data in R to support epidemiological and genetic analyses.

Key Features:

• Data Integration: Integrates UK Biobank main dataset with record-level data files for comprehensive phenotype derivation.
• Harmonization and Processing: Implements a protocol to harmonize disparate UK Biobank data types into a consistent, analysis-ready format.
• Binary Phenotype Generation: Produces standardized binary phenotypes that are machine-actionable for downstream computational analyses.
• Reproducibility and Standardization: Provides reproducible, standardized phenotype definitions to support consistent analytical workflows.

Scientific Applications:

• Epidemiological research: Enables phenotype definition for large-scale cohort analyses within the UK Biobank.
• Genetic association studies: Supplies standardized binary phenotypes for testing associations between genetic variants and specific health conditions.
• Translational and public health research: Facilitates analyses that inform personalized medicine and population-level health strategies.

Methodology:

Implements the structured protocol for data integration and harmonization described by Yeung et al. (2022) to process UK Biobank main and record-level data into standardized binary phenotypes.