UniCarb-DB

UniCarb-DB provides a curated database of LC-MS/MS-characterized oligosaccharide structures and associated fragment data to support glycan structure profiling and analysis of protein glycosylation.

Key Features:

• LC-MS/MS-characterized structures: Oligosaccharide structures derived from liquid chromatography–tandem mass spectrometry datasets.
• Fragment ion data: Inclusion of MS/MS fragment spectra linked to structural assignments.
• Curated annotations and high-quality datasets: Meticulously annotated entries with quality-controlled dataset metadata.
• Standards and ontologies mapping: Integration and mappings to existing glycomics standards and ontologies developed by other databases.
• Support for glycan profiling and high-throughput analysis: Data structured to enable glycan structure profiling and large-scale glycomics studies.

Scientific Applications:

• Glycan structure elucidation: Use of LC-MS/MS spectra and fragment data to determine oligosaccharide structures.
• Protein glycosylation analysis: Investigation of glycosylation roles in pathogen recognition, innate immune response, and epithelial membrane protection.
• High-throughput glycomics: Support for large-scale glycan profiling and comparative glycomics studies.
• Bioinformatics and glycobiology analyses: Reference datasets for computational analyses and development of glycomics tools.

Methodology:

Provides LC-MS/MS-derived oligosaccharide structures with associated MS/MS fragment spectra, meticulously annotated datasets, and mappings to existing glycomics standards and ontologies.