UniCarbKB

UniCarbKB catalogs curated glycan structures associated with glycoproteins to support analysis of glycosylation and its biological implications.

Key Features:

• Curated Glycan Structures: Contains over 3,740 curated glycan entries derived from glycoproteins, including global and site-specific attachment details.
• Integration with Existing Databases: Builds upon GlycoSuiteDB, incorporates EUROCarbDB informatic standards, and integrates data with UniProtKB and GlycoMod.
• Experimental Annotations: Provides annotations for 598 protein glycosylation sites confirmed by experimental evidence from the literature.
• Expanded Content: Includes over 890 references, 35 additional glycoproteins, 502 new structures, and 60 publications not previously covered by GlycoSuiteDB.

Scientific Applications:

• Glycosylation research: Supports studies into the roles of glycosylation in biological processes and disease mechanisms.
• Glycan-mediated pathway analysis: Enables exploration of glycan-mediated pathways using curated structural and site-specific data.
• Protein–glycan interaction studies: Facilitates characterization and comparison of protein–glycan interactions informed by experimental site annotations.
• Therapeutic development: Provides reference data to support development of glyco-targeted therapeutic strategies and biomarker discovery.

Methodology:

Incorporates EUROCarbDB informatic standards, builds on GlycoSuiteDB content, and integrates curated glycan and glycosylation-site data with UniProtKB and GlycoMod.