UniProt Align

UniProt Align performs multiple sequence alignment of protein sequences using UniProt sequence and annotation data to support comparative proteomics and functional inference.

Key Features:

• Extensive Sequence Database: Uses the UniProt database of over 80 million protein sequences, including many derived from genome sequencing projects, as the reference for alignments.
• Proteome Identifier System: Incorporates UniProt's proteome identifier system that uniquely labels assemblies of species, strains, or subspecies to track sequence provenance.
• Annotation Scores: Utilizes UniProt annotation scores assigned to entries to prioritize well-characterized proteins during analysis.

Scientific Applications:

• Comparative Proteomics: Aligns proteins from different organisms or strains to reveal evolutionary relationships and functional divergence.
• Functional Annotation: Supports annotation of novel protein sequences by comparison to well-characterized UniProt entries and their annotation scores.
• Proteome Studies: Enables proteome-wide analyses by applying alignments at scale across proteomes identified in UniProt.

Methodology:

Performs multiple sequence alignments using advanced algorithms and integrates UniProt annotation scores and proteome identifiers from the UniProt database.