UniTmp

UniTmp provides comprehensive structural and topology annotations for transmembrane proteins by integrating TOPDB, TOPDOM, PDBTM, and HTP to unify segment localization, protein topology, and membrane-embedded 3D structure information.

Key Features:

• Database integration: Integrates data from TOPDB, TOPDOM, PDBTM, and HTP to unify annotations across specialized resources.
• Multi-level structural information: Provides segment localization, protein topology, and detailed 3D structures embedded in membranes.
• Membrane-embedded structures: Contains 9,235 membrane-embedded structures.
• Topology-annotated sequences: Includes 9,088 sequences with 536,035 topology-annotated segments.
• Conserved domains and motifs: Contains 8,692 conservatively localized protein domains or motifs.
• Human transmembrane proteome annotations: Provides annotations for 5,466 human transmembrane proteins.
• Parallel serving and interoperability: Serves integrated resources in parallel to enable interoperability and efficient data retrieval.
• Regular updates: Maintains regular updates of the integrated datasets.

Scientific Applications:

• Structural biology: Supports analysis of membrane-embedded 3D structures for structural biology studies.
• Topology and segment mapping: Enables comparative study of segment localization and protein topology across datasets.
• Domain and motif analysis: Facilitates analysis of conservatively localized domains and motifs in transmembrane proteins.
• Human protein and disease research: Supports investigation of human transmembrane proteins and their roles in biological processes and disease.

Methodology:

Integrates TOPDB, TOPDOM, PDBTM, and HTP and serves these resources in parallel to provide unified annotations and regular updates.