UPB

UPB aggregates curated urinary protein biomarker records from human and animal studies to support proteomic biomarker discovery and comparative analyses.

Key Features:

• Comprehensive Data Collection: Compiles data from 174 human study publications and 31 animal study publications, comprising 553 human records and 275 animal records.
• Manual Curation for Quality Assurance: All literature entries were manually curated to ensure data quality and relevance.
• Biomarker Validation Support: Enables determination of whether a protein biomarker has been previously reported for the same or different diseases to support candidate selection for validation.
• Pathophysiological Insights: Facilitates cross-study comparisons to investigate shared biomarkers and potential common pathophysiological mechanisms.
• Focus on Urological Diseases: Emphasizes urinary protein biomarkers relevant to the pathogenesis of urological diseases.
• Comparative Proteomics Metadata: Records include information on sample preparation, separation techniques, mass spectrometry technologies, and data analysis algorithms.

Scientific Applications:

• Disease Biomarker Discovery: Identification and prioritization of urinary protein candidates for disease-specific biomarker studies.
• Comparative Proteomics Studies: Assessment of how sample preparation, separation methods, mass spectrometry technologies, and data analysis algorithms influence biomarker identification.
• Animal Model Evaluation: Evaluation of concordance between animal model-derived urinary biomarkers and human samples.

Methodology:

Construction involved literature review, extraction of data from published human and animal studies, and manual curation.