UPIMAPI

UPIMAPI performs sequence homology-based annotation of omics and meta-omics datasets by aligning input sequences to UniProtKB to derive functional information for microbial function exploration.

Key Features:

• Sequence homology-based annotation: Aligns input sequences to UniProtKB entries to infer functional annotations from homologous proteins.
• Integration with UniProtKB: Extracts protein names, Enzyme Commission (EC) numbers, Gene Ontology (GO) terms, taxonomy data, and cross-references to external databases from UniProtKB entries.
• Scalability for omics and meta-omics datasets: Processes large-scale metagenomic, metatranscriptomic, and metaproteomic sequence files for comprehensive annotation.

Scientific Applications:

• Metagenomics annotation: Provides functional annotation of metagenomic sequences via homology to UniProtKB entries.
• Metatranscriptomics annotation: Enables assignment of functional terms to metatranscriptomic sequences using UniProtKB-derived annotations.
• Metaproteomics annotation: Facilitates mapping of peptide or protein sequences from metaproteomics datasets to UniProtKB functions.
• Microbial functional interpretation: Supports interpretation of microbial activities in natural environments and biotechnological processes through comprehensive functional annotations.

Methodology:

Aligns input sequences against UniProtKB entries using sequence homology to derive functional annotations and extract protein names, EC numbers, GO terms, taxonomy data, and cross-references.