VANESA

VANESA reconstructs and analyzes biological networks to model molecular interactions and system dynamics.

Key Features:

• Automatic Network Reconstruction: Uses database resources including KEGG, MINT, IntAct, HPRD, and BRENDA to automatically reconstruct molecular systems as networks.
• Integration with Experimental Data: Incorporates experimental datasets with database information to enrich context for network elements and processes.
• Graph Theoretical Approaches: Applies graph theory to identify regulatory structures and key components within modeled networks.
• Petri Net Environment: Provides a Petri net environment for dynamic modeling and simulation of biochemical processes.

Scientific Applications:

• Systems Biology: Modeling and analysis of complex molecular interaction networks and regulatory structures.
• Biomedical Research: Investigation of regulatory mechanisms and identification of potential therapeutic targets within reconstructed networks.

Methodology:

Integration of KEGG, MINT, IntAct, HPRD, and BRENDA data with experimental datasets, followed by graph-theoretical analysis and Petri net–based dynamic modeling and simulations.