VaximmutorDB

VaximmutorDB curates and organizes vaccine-induced immune factors ("vaximmutors") to enable analysis of immune responses and pathway enrichment across vaccines and host species.

Key Features:

• Comprehensive Data Collection: Curates 1,740 vaccine-induced immune factors from peer-reviewed articles across 13 host species, linked to 154 vaccines targeting 46 pathogens.
• Top Immune Factors: Highlights top vaximmutors including antibodies IgG, IgG2a, IgG1; Th1 factors IFN-γ and IL-2; Th2 factors IL-4 and IL-6; TNF-α; CASP-1; and TLR8.
• Pathway Analysis: Identifies enriched host processes and cellular components such as the stimulatory C-type lectin receptor signaling pathway and SRP-dependent cotranslational protein targeting to membranes.
• Model Studies (Influenza): Demonstrates differential vaccine-associated pathways, e.g., FluMist-associated signal transduction responses versus Fluarix-associated protein metabolism responses.
• Comparative Analysis: Enables direct comparison of vaccine studies, exemplified by overlapping gene lists and shared pathways between two YF‑Vax studies despite study-specific differences.

Scientific Applications:

• Vaccine Development: Provides curated vaximmutors and pathway enrichment results to inform selection of immune targets and mechanistic hypotheses for vaccine design.
• Disease Diagnosis: Supplies candidate immune markers derived from vaccine responses that can be evaluated for diagnostic or monitoring use.
• Immunity Analysis: Supports analysis of host immunity mechanisms across species and pathogens by linking vaximmutors to biological processes and pathways.

Methodology:

Data were systematically curated from peer-reviewed articles, stored in the database, and analyzed to identify vaximmutors, rank top immune factors, perform pathway enrichment analyses (including identification of specific pathways and cellular components), and conduct comparative analyses across vaccines and studies.