Variant Effect Predictor (VEP)

Variant Effect Predictor (VEP) annotates and prioritizes genomic variants across coding and non-coding regions to enable interpretation across diverse genomes including vertebrates, plants, fungi, protists, metazoa, and bacteria.

Key Features:

• Variant annotation: Performs annotation of genomic variants using an extensive collection of genomic annotations.
• Variant prioritization: Prioritizes variants to aid identification of biologically relevant changes.
• Multi-kingdom genome support: Supports genomes of vertebrates, plants, fungi, protists, metazoa, and bacteria.
• Coding and non-coding analysis: Annotates and interprets variants in both coding and non-coding regions.
• Extensive genomic annotations: Leverages a broad set of genomic annotations to enhance interpretation accuracy.
• Configurable and extensible analyses: Provides configurable options to extend and customize analyses.

Scientific Applications:

• Basic research variant interpretation: Provides annotations and prioritization to support variant interpretation in basic research.
• Clinical variant interpretation: Annotates potential impacts of genomic variants to support clinical prioritization and interpretation.
• Cross-taxa genomic studies: Enables analysis and interpretation of variants across diverse genomes for comparative and multi-species studies.

Methodology:

Annotates and prioritizes variants using genomic annotations with configurable options to extend analyses across coding and non-coding regions and multiple genomes.