VExD

VExD compiles and uniformly processes human gene expression datasets to characterize host transcriptional changes before and after viral infection.

Key Features:

• Comprehensive Data Collection: Approximately 8,000 samples from 289 studies covering 51 distinct human viruses.
• Uniform Processing Pipeline: A standardized processing pipeline ensures consistency across datasets and enables detection of antiviral responses, including interferon-stimulated genes.
• Enhanced Metadata: Specialized metadata annotations facilitate identification of experiments relevant to viral infection and host response.

Scientific Applications:

• Antiviral Response Analysis: Enables analysis of host transcriptional responses to viral infection, including interferon-mediated pathways.
• Virus Life Cycle Studies: Supports investigation of how viruses manipulate host gene expression to promote replication and evade immune detection.
• Experimental Support: Provides datasets for validating and supporting experiments conducted in human cells and model organisms.

Methodology:

Collection of gene expression datasets from published studies followed by a rigorous, standardized processing pipeline to ensure uniformity across datasets and capture known antiviral responses such as interferon-stimulated genes.