VEXOR

VEXOR prioritizes functional genetic variants in fine-mapping analyses by integrating GWAS association results with genomic annotations, reference tools, and experimental data.

Key Features:

• Integrative annotation consolidation: Consolidates multiple annotation tools and reference datasets to annotate genetic variants by genomic location and predicted functionality.
• Association-to-reference linking: Links GWAS association results with reference tools and experimental datasets to contextualize variant signals within fine-mapping regions.
• Predictive functional prioritization: Prioritizes candidate variants by predicting potential functional implications relevant to phenotypic traits and disease susceptibility.

Scientific Applications:

• Post-GWAS fine-mapping: Supports fine-mapping analyses to identify and rank candidate causal variants within GWAS-associated loci.
• Functional interpretation of variants: Facilitates interpretation of variant effects to generate hypotheses about genetic contributions to diseases and traits.

Methodology:

Combines multiple reference tools and datasets by linking GWAS association results with genomic annotations and experimental data to enable variant annotation and prioritization.