VGSC-DB

VGSC-DB provides a curated database of voltage-gated sodium channel (VGSC/Na_v) modulators and associated experimental annotations to support research and drug discovery targeting Na_v1.1–Na_v1.9.

Key Features:

• Extensive data collection: Contains 6,055 data records derived from 173 literature references encompassing 3,396 compounds that target nine Na_v subtypes (Na_v1.1–Na_v1.9).
• Comprehensive record fields: Each record comprises 28 detailed items, including chemical structures, biological activities (IC50/EC50), target specificity, binding site annotations, organism information, and chemical/physical properties.
• Diverse compound types: Aggregates data for small-molecule compounds, toxins, and their derivatives.
• Advanced query support: Supports text and structure queries and enables batch querying for large-scale retrieval.

Scientific Applications:

• Drug discovery: Provides compound and activity data to support development of subtype-selective Na_v modulators.
• Pharmacology and mechanism studies: Supplies binding site annotations and activity measurements for analysis of modulatory mechanisms across Na_v subtypes.
• Disease-focused research: Supports investigation of VGSC roles in diseases such as epilepsy, migraine, and ataxia through annotated modulators.
• Cheminformatics and modeling: Offers chemical structures and physicochemical properties for structure–activity analysis, virtual screening, and modeling.

Methodology:

Data were aggregated from 173 references into 6,055 records covering 3,396 compounds with 28 annotated fields per record; the dataset supports text and structure queries, batch querying, and export in XLSX and SDF formats.