Vienna RNA Package

Vienna RNA Package predicts RNA secondary structures and provides computational tools for consensus structure prediction and sequence design to study RNA structure–function relationships.

Key Features:

• C code library and standalone programs: Provides a C code library and multiple standalone programs for computational analysis of RNA.
• Secondary Structure Prediction: Predicts RNA secondary structures from individual sequences.
• Consensus Secondary Structure Prediction: Predicts consensus secondary structures from aligned RNA sequences.
• Sequence Design: Designs RNA sequences that fold into predefined target secondary structures.

Scientific Applications:

• Functional Genomics: Predicts and analyzes RNA secondary structures to infer potential functional roles of non-coding RNAs.
• Comparative Genomics: Identifies conserved structural elements across species using consensus secondary structure prediction from alignments.
• Synthetic Biology: Supports design of novel RNA molecules with specified secondary structures for experimental or therapeutic purposes.

Methodology:

Implements computational algorithms to model RNA folding and interactions via a C code library and standalone programs.