Vir2Drug

Vir2Drug prioritizes and ranks candidate repurposed drugs by leveraging pathogen-to-pathogen and host protein similarities to identify therapeutics against specific pathogens.

Key Features:

• Network-Based Analysis: Constructs pathogen-to-pathogen networks based on ranked protein similarities between pathogens for use in drug screening.
• Taxonomy Distance: Computes taxonomy distance as a metric of evolutionary relatedness to refine the selection and ranking of candidate drugs.
• Drug Target Integration: Incorporates drug targeting information that maps drugs to specific pathogen and host proteins to inform repurposing candidates.
• Methodological Flexibility: Applies distinct computational methodologies tailored to evaluate host protein targets versus pathogen protein targets.

Scientific Applications:

• Outbreak Drug Repurposing: Rapidly identifies and ranks repurposed drug candidates for emerging viral outbreaks to provide immediate therapeutic options prior to vaccine availability.
• Therapeutic Prioritization: Prioritizes candidate therapeutics for known or emerging pathogens by integrating protein similarity and taxonomy distance metrics.

Methodology:

Constructing pathogen networks based on protein similarities; integrating taxonomy distance to refine candidate selection; and screening drugs using methodologies that consider both host and pathogen protein targets.