ViRBase v3.0

ViRBase v3.0 catalogs virus and host non-coding RNA (ncRNA)-associated interactions to support research into viral infection mechanisms.

Key Features:

• Expanded Interaction Database: Contains over 820,000 interaction entries covering 116 virus species and 36 host organisms.
• Enhanced RNA Annotations: Includes detailed annotations for RNA editing, localization, and modification.
• ncRNA SNP and Drug Associations: Provides non-coding RNA single nucleotide polymorphism (SNP) data and associations between ncRNAs and drugs.
• Predictive Tools: Integrates IntaRNA and PRIdictor to identify potential binding sites within RNA sequences.
• Visual Interaction Display: Includes a visual plug-in for graphical display of interaction networks.

Scientific Applications:

• Identification of antiviral targets: Supports identification of novel antiviral targets through compiled ncRNA–virus interaction data.
• Study of viral pathogenesis: Enables investigation of ncRNA roles in viral pathogenesis.
• Therapeutic exploration: Facilitates exploration of potential therapeutic interventions via ncRNA–drug associations and predictive binding analyses.
• Support for virology and molecular biology research: Serves virologists, molecular biologists, and bioinformaticians studying viral infections.

Methodology:

Database entries include annotations for RNA editing, localization, and modification and ncRNA SNP–drug associations; IntaRNA and PRIdictor are provided for binding-site prediction; a visual plug-in is integrated for graphical interaction display.