VIRGO

VIRGO provides a curated non-redundant gene catalog and derived vaginal orthologous groups (VOG) for analysis of metagenomic and metatranscriptomic data from the human vaginal microbiome.

Key Features:

• Comprehensive Non-Redundant Gene Catalog (VIRGO): Approximately 0.95 million non-redundant genes representing the genetic diversity of the human vaginal microbiome with functional and taxonomic annotations.
• Vaginal Orthologous Groups (VOG): Orthologous groups derived from VIRGO that enable comparative analyses of evolutionary relationships and functional conservation across vaginal microbial species.
• Gene-Centric Design: A gene-centric organization that supports characterization of structure and function in vaginal metagenome and metatranscriptome datasets.

Scientific Applications:

• Intraspecies Diversity Analysis: Analysis of 1,507 additional vaginal metagenomes to reveal extensive intraspecies diversity within the vaginal microbiota.
• Reference for Functional and Taxonomic Studies: A reference database to support detailed investigations of microbial roles, interactions, and implications for women's health and reproductive biology.

Methodology:

Assembling a non-redundant gene catalog from metagenomic data, performing functional and taxonomic annotation, and constructing VOGs from VIRGO.