VirhostlncR

VirhostlncR catalogs long non-coding RNAs (lncRNAs) modulated during viral infections to support analysis of their roles in host–virus regulatory networks.

Key Features:

• Extensive Dataset: Includes 2803 lncRNAs modulated by 33 viral strains across diverse mammalian cell types.
• Viral and Host Metadata: Integrates multiplicity of infection, duration of infection, host cell name, and cell type for each entry.
• Expression Analysis: Provides fold change data on lncRNA expression under infection conditions.
• Identification Methods: Documents the specific methods used to identify each lncRNA.
• Recurrently Perturbed lncRNAs: Reports 150 lncRNAs perturbed by two or more viruses, including DANCR, MALAT1, MEG3, NEAT1, and PVT1.
• Viral protein–TF Interaction Integration: Integrates viral protein interactions with human transcription factors and TF-containing protein complexes to reveal regulatory networks.
• Prioritization: Enables prioritization of lncRNAs based on their perturbation across multiple viral infections.

Scientific Applications:

• Functional Analysis: Understanding roles of specific lncRNAs in viral emergence, regulation, and progression.
• Transcriptional Regulation Studies: Investigating how viruses transcriptionally regulate lncRNAs via interactions with human transcription factors and TF-containing protein complexes.
• Noncoding RNA Research: Analyzing noncoding RNA–mediated regulation in infections including influenza, hepatitis, coronavirus, and HIV.

Methodology:

Compilation of data from diverse sources; integration of viral protein interactions with human transcription factors and TF-containing protein complexes to identify regulatory networks; prioritization of lncRNAs based on perturbation across multiple viral infections.