VirMutSig

VirMutSig identifies and assigns viral mutational signatures from sequencing data to characterize nucleotide substitution patterns indicative of underlying mutational processes.

Key Features:

• De Novo Discovery: Facilitates de novo discovery of mutational signatures directly from raw viral sequencing data to detect novel nucleotide substitution patterns.
• Association with Existing Signatures: Assigns discovered or pre-existing viral mutational signatures to specific samples within a dataset to characterize sample-level mutational processes.
• Comprehensive Protocol: Implements the VirMutSig protocol for discovery and association of viral mutational signatures as described by Graudenzi et al. (2021).

Scientific Applications:

• Viral Evolution Studies: Identifying mutational signatures to inform analyses of viral evolutionary dynamics.
• Epidemiological Tracking: Assessing how different mutational processes influence viral spread and adaptation.
• Drug Resistance Research: Investigating mutational patterns relevant to the development of antiviral drug resistance.

Methodology:

De novo discovery of mutational signatures from raw viral sequencing data and assignment/association of signatures to samples following the VirMutSig protocol (Graudenzi et al., 2021).