VIRUS-MVP

VIRUS-MVP enables comprehensive surveillance of viral mutations by linking them to functional annotations and providing insights into their predicted effects on viral infectivity, immune evasion, and protein functionality.

Key Features:

• Interactive mutation visualization: The platform visualizes mutation distributions interactively.
• Modular genomics workflow: A reproducible workflow supports mutation surveillance across multiple viruses.
• Curated annotation resource: Captures known impacts of mutations on viral proteins and host interactions.
• Custom annotation import: Users can import custom functional annotations to tailor analyses to specific research needs or emerging pathogens.
• Multi-virus support: Initially developed for SARS-CoV-2, the platform fully supports mpox and is expanding to include influenza and RSV.

Scientific Applications:

• Viral mutation surveillance: Tracks genetic mutations that influence disease severity, transmissibility, and effectiveness of vaccines and therapeutics.
• Functional impact prediction: Provides insights into predicted effects of mutations on viral infectivity, immune evasion, and protein functionality.
• Public health response assessment: Supports real-time tracking to understand viral evolution and assess implications for public health responses.

Methodology:

The platform links viral mutations to functional annotations through a curated annotation resource and enables users to import custom functional annotations.