VirusMentha

VirusMentha aggregates curated virus-host and virus-virus protein-protein interaction data to provide a comprehensive resource for studying how viral proteins perturb host cellular processes.

Key Features:

• Curated interaction data: Integrates evidence from multiple manually curated protein-protein interaction databases under the curation standards of the IMEx consortium and mentha/VirusMINT protocols.
• Regular automated updates: Captures new interactions on a weekly basis via automated retrieval using the PSICQUIC protocol from five IMEx member databases.
• Comprehensive interaction coverage: Includes both virus-host and virus-virus protein-protein interactions to represent viral perturbations of the host interactome.

Scientific Applications:

• Mapping viral perturbations: Enables analysis of how viral proteins interact with host proteins to disrupt cellular processes and complexes.
• Antiviral target identification: Supports identification of host and viral proteins that may serve as targets for antiviral intervention based on documented PPIs.
• Basic virology research: Facilitates studies of virus-virus and virus-host interaction dynamics to elucidate mechanisms of infection and host response.

Methodology:

Data integration follows mentha and VirusMINT curation protocols aligned with IMEx consortium standards, with weekly automated data retrieval via the PSICQUIC protocol aggregating updates from five IMEx member databases.