VirusMINT

VirusMINT catalogs and annotates interactions between human and viral proteins to document virus-induced perturbations in the human protein interaction network.

Key Features:

• Comprehensive Interaction Data: Contains over 5,000 documented interactions involving more than 490 unique viral proteins from over 110 different viral strains.
• Focused Curation on Medically Relevant Viruses: Emphasizes interactions involving papilloma viruses, human immunodeficiency virus 1 (HIV-1), Epstein-Barr virus, hepatitis B virus, hepatitis C virus, herpesviruses, and Simian virus 40.
• Annotation of Network Perturbations: Records perturbations of the cellular protein interaction network induced by virus-encoded proteins.

Scientific Applications:

• Viral pathogenesis studies: Supports analysis of how viral proteins interact with host machinery to drive disease processes.
• Host response and mechanism research: Enables investigation of host cellular pathways affected by viral infection.
• Therapeutic target identification: Facilitates identification of human proteins and interactions that may serve as antiviral targets.
• Systems-level interaction mapping: Integrates viral–human interactions within the broader human protein interaction network for network-based analyses.

Methodology:

Manual curation from scientific literature with annotation and storage of reported viral–human protein interactions.