ViruSurf

ViruSurf aggregates and curates viral sequence data and computes nucleotide and amino acid variants to support comparative genomics and epidemiological analyses.

Key Features:

• Metadata integration: Integrates and curates metadata from RefSeq, GenBank, COG-UK, NMDC, and a GISAID-specific subset.
• Computed variants: Provides computed nucleotide and amino acid variants derived directly from original sequences.
• Multidimensional description: Describes sequences across biological, technological, organizational, and analytical dimensions.
• Sequence annotations: Supplies sequence annotations and variant information for analytical characterization.
• Viral coverage: Includes human-affecting viruses such as SARS-CoV-2, SARS-CoV, MERS-CoV, Ebola, and Dengue.
• Temporal and population analyses: Supports recomputation of results over time and across different populations.
• Scale of data: Maintains large volumes of curated sequence data for integrative analyses.

Scientific Applications:

• Comparative genomics: Compare genomes and variant patterns across datasets and viral strains.
• Variant surveillance: Monitor emergence and distribution of nucleotide and amino acid variants over time and geography.
• Epidemiological and outbreak analysis: Support molecular surveillance and response to emerging viral threats via recomputable analyses.
• Integrative cross-dataset studies: Combine RefSeq, GenBank, COG-UK, NMDC, and GISAID data for integrative investigations.
• Functional and evolutionary studies: Use annotations and variant data for functional interpretation and evolutionary inference.

Methodology:

Integration and curation of metadata from RefSeq, GenBank, COG-UK, NMDC and a GISAID-specific subset; computation of nucleotide and amino acid variants from original sequences; annotation and characterization of sequences across biological, technological, organizational, and analytical dimensions; support for recomputation of results over time and across populations.