VISMapper

VISMapper maps retroviral vector integration sites from next-generation sequencing data to identify and characterize integration events relevant to gene therapy safety.

Key Features:

• High-speed mapping algorithms: Employs novel mapping algorithms for ultra-fast alignment and mapping of sequencing reads to detect integration sites from next-generation sequencing (NGS) data.
• Integration site characterization: Identifies and characterizes retroviral vector integration sites, providing information relevant to insertional mutagenesis and oncogene activation.

Scientific Applications:

• Risk Assessment: Maps integration sites to assess potential insertional mutagenesis and activation of oncogenes in gene therapy studies.
• Vector Development: Identifies integration patterns and hotspots to inform the design of safer viral vectors.

Methodology:

Processes next-generation sequencing data using novel high-speed mapping algorithms tailored for detection and characterization of retroviral vector integration sites.