VisTCR

VisTCR analyzes high-throughput T cell receptor (TCR) sequencing data to visualize and characterize T cell repertoire diversity and clonality.

Key Features:

• Interactive Visualization: Provides visualizations of high-throughput TCR sequencing data for exploring repertoire composition and clonality.
• Hierarchical Data Analysis: Integrates multiple cutting-edge TCR analysis algorithms in a hierarchical framework for comprehensive repertoire analysis.
• Customizable Experiment Design: Supports grouping and regrouping of samples via an "Experiment Design File" to define experimental comparisons.
• Data Storage and Export: Includes data storage and export of analysis results in formats such as tables and graphs.

Scientific Applications:

• TCR diversity and clonality analysis: Characterizes T cell repertoire diversity and clonal expansions from sequencing data.
• Infection studies: Assesses immune responses to infections by tracking TCR repertoire changes.
• Vaccine research: Evaluates vaccine-induced T cell repertoire dynamics.
• Autoimmune disease research: Investigates TCR repertoires associated with autoimmune conditions.
• Cancer immunotherapy: Analyzes TCR repertoire features relevant to cancer immunotherapy responses.

Methodology:

Processes high-throughput TCR sequencing data using integrated TCR analysis algorithms in a hierarchical manner, with support for visualization, sample grouping via an "Experiment Design File," and storage/export of results as tables or graphs.