WARE

WARE evaluates individual risk for wet age-related macular degeneration (AMD) by integrating genetic and non-genetic factors normalized to population frequencies and disease prevalence.

Key Features:

• Risk calculation: Computes individualized risk profiles for wet AMD by combining multiple genetic and non-genetic factors.
• Genetic normalization: Normalizes genetic risk measures based on relative allele frequencies in the general population and on disease prevalence.
• Population customization: Allows adjustment of genetic factor weights, allele frequencies, non-genetic influences, and local disease prevalence for different populations.
• Risk stratification plots: Generates visual population risk distributions that delineate low-risk and high-risk zones.
• Clinical risk stratification: Produces risk scores intended to inform follow-up schedules and treatment protocol decisions for patients with or at risk of wet AMD.

Scientific Applications:

• Personalized follow-up and treatment planning: Uses individualized risk profiles to guide frequency of monitoring and therapeutic decisions for wet AMD.
• Preventive intervention prioritization: Identifies individuals at elevated risk to target preventive measures aimed at reducing progression to wet AMD.
• Population-specific risk assessment: Supports evaluation of AMD risk across different demographic or genetic populations by adjusting allele frequencies and prevalence.
• Risk communication: Provides quantitative risk stratification and plots to support clinician–patient discussions about AMD risk.

Methodology:

Computes individual risk scores by integrating genetic and non-genetic factors; normalizes genetic risk measures by relative allele frequencies and disease prevalence; permits adjustments for population-specific genetic frequencies and non-genetic influences; generates population risk distribution plots with delineated low- and high-risk zones.