WatCon

WatCon analyzes conserved water networks across protein families using both dynamic and static structural information.

Key Features:

• Water Network Conservation Classification: WatCon classifies conservation of water networks across related proteins.
• Water Network Characterization: WatCon characterizes water networks across structures.
• Result Projection: WatCon projects results for visual interpretation.
• Dynamic and Static Structure Support: WatCon analyzes both dynamic trajectories and static structures.
• Cross-Family Analysis: WatCon enables analysis across protein families.

Scientific Applications:

• Static Structure Analysis: WatCon analyzes water positions and networks in static protein structures.
• Dynamic Trajectory Analysis: WatCon analyzes water networks in molecular dynamics trajectories.
• Cross-Family Comparison: WatCon compares water networks across related protein families.
• Water Hotspot Prediction: WatCon predicts water hotspots relevant to protein engineering.
• Pathogenic Mutation Prediction: WatCon predicts pathogenic mutations based on water network analysis.

Methodology:

WatCon uses graph-theory-based methods to describe hydrogen-bonding networks formed by water molecules and protein residues.