WebTetrado

WebTetrado analyzes three-dimensional nucleic-acid quadruplex structures to identify, annotate, classify, and visualize quadruplex and quartet motifs for structural and functional studies.

Key Features:

• Automatic identification and annotation: Identifies quadruplex motifs within nucleic-acid 3D models and annotates them with detailed structural characteristics.
• Classification: Distinguishes canonical G-quadruplexes from non-G-based quartets and assigns classification categories to quadruplex folds.
• Visualization: Generates visual representations of complex quadruplex 3D folds to support structural inspection.
• Quadruplex types supported: Supports unimolecular, bimolecular, and tetramolecular quadruplex topologies.
• Input format compatibility: Processes experimentally derived and in silico 3D models in PDB and PDBx/mmCIF formats.

Scientific Applications:

• Structural biology of nucleic acids: Characterizing 3D folds of nucleic-acid quadruplexes.
• Functional role analysis: Relating quadruplex 3D features to regulatory functions in genomes.
• Therapeutic targeting and drug discovery: Identifying structural motifs and features relevant for targeting quadruplexes in drug design.
• Comparative studies: Enabling comparison of canonical G-quadruplexes and non-G-based quartets across models.

Methodology:

The input does not specify computational algorithms or detailed processing steps used for identification, annotation, classification, or visualization.