WGCCRR

WGCCRR screens convergent and lineage-specific amino acid indels and substitutions across whole genomes to identify candidate loci for adaptive evolution.

Key Features:

• Genome-wide screening: Analyzes protein-coding gene sequences across entire genomes for convergent, parallel, and lineage-specific changes.
• Amino acid substitution detection: Identifies convergent, parallel, and lineage-specific amino acid substitutions.
• Indel detection: Includes amino acid indels that are typically neglected in comparable analyses.
• Comparative coding region analysis: Processes whole genome comparative coding region read data.

Scientific Applications:

• Adaptive evolution screening: Facilitates identification of genetic loci with potential roles in adaptive evolution across diverse organismal groups.
• Convergent evolution research: Enables detection of convergent and parallel amino acid changes implicated in similar adaptive phenotypes.
• Lineage-specific trait analysis: Supports correlation of lineage-specific amino acid changes with lineage-specific traits.
• Candidate locus prioritization: Generates results for downstream experimental validation of causality.

Methodology:

The tool performs whole genome comparative coding region read analysis to screen for convergent, parallel, and lineage-specific amino acid substitutions and indels in protein-coding gene sequences.