The world-2DPAGE database

World-2DPAGE provides access to standardized gel-based proteomics (2D-PAGE) image datasets linked to protein identifications to support proteomics analyses.

Key Features:

• World-2DPAGE Repository: The World-2DPAGE Repository houses gel-based proteomics (2D-PAGE) data linked to protein identifications reported in the literature and follows data standards.
• WORLD-2DPAGE List of 2-D PAGE database servers: The WORLD-2DPAGE List of 2-D PAGE database servers catalogs existing databases dedicated to 2D-PAGE data to support integration.
• World-2DPAGE Portal: The World-2DPAGE Portal enables querying of multiple proteomics databases simultaneously.
• Make2D-DB package: The Make2D-DB package provides functionality to create SWISS-2DPAGE-like databases for web deployment.

Scientific Applications:

• Protein expression profiling: Supports analysis of protein expression patterns derived from 2D-PAGE images.
• Biomarker discovery: Facilitates identification of protein biomarkers through comparison of gel-based datasets and protein identifications.
• Comparative proteomics analyses: Enables cross-dataset comparisons of 2D-PAGE results across multiple databases.
• Reproducibility and validation: Provides standardized datasets and linked identifications to support reproducibility and validation of proteomics experiments.

Methodology:

The platform uses informatics tools for data standardization and interoperability; the Make2D-DB package facilitates creation of databases that adhere to established proteomics data standards.