wrmXpress

wrmXpress analyzes high-content imaging datasets to quantify diverse phenotypes in parasitic and free-living nematodes and flatworms for phenotypic characterization and anthelmintic screening.

Key Features:

• Unified framework: Processes large datasets from high-throughput and high-content imaging technologies within a single analytical framework applicable across experimental setups.
• Phenotypic analysis capabilities: Quantifies multiple phenotypes including motility, development/size, fecundity, and feeding behaviors in nematodes and flatworms.
• Modular architecture and extensibility: Provides a modular package that supports addition and customization of phenotypic analysis modules.
• Anthelmintic screening utility: Supports phenotypic analyses relevant to anthelmintic screening across species such as schistosomes, filarial nematodes, and free-living model nematodes.
• Support for collaborative research: Offers a unified analysis platform that facilitates integration of diverse phenotypic datasets for cross-study comparisons.

Scientific Applications:

• Phenotypic characterization: Quantifies behavioral and developmental phenotypes in parasitic and free-living worms under varied experimental conditions.
• Anthelmintic drug screening: Enables assessment of drug response phenotypes across multiple worm species for screening and comparative analyses.
• Developmental and behavioral biology: Supports studies of growth, size, fecundity, feeding, and motility to investigate worm biology and physiology.

Methodology:

Processes large datasets generated by high-throughput and high-content imaging technologies within a modular, extensible framework to analyze motility, development/size, fecundity, and feeding behaviors in nematodes and flatworms.