XPRESSyourself

XPRESSyourself standardizes and automates computational analysis of ribosome profiling and RNA-seq data to quantify ribosome activity and protein translation dynamics.

Key Features:

• Automation and Standardization: Automates complex analysis procedures and standardizes analyses to improve reproducibility.
• Ribosome profiling and RNA-seq analysis: Performs computational analysis of ribosome profiling and RNA-seq data to monitor ribosome activity.
• Best Practices Implementation: Implements current best practices in ribosome profiling analysis as a reference implementation.

Scientific Applications:

• Neurodegenerative mechanism identification: Supports identification of mechanisms associated with neurodegenerative phenotypes from ribosome profiling and RNA-seq data.
• ISRIB mechanism investigation: Enables exploration of neuroprotective mechanisms of the small-molecule ISRIB during acute cellular stress using ribosome profiling and RNA-seq.

Methodology:

Performs computational analysis of ribosome profiling and RNA-seq data, leveraging nucleic acid sequencing to monitor ribosome activity and provide insights into protein translation dynamics while automating and standardizing complex analysis procedures.