XSI

XSI compresses genotype data into a specialized file format that reduces storage and enables direct computation on compressed whole-genome sequencing (WGS) and biobank-scale datasets.

Key Features:

• Reduced Storage Footprint: Achieves a 4–20× reduction in file size compared to traditional Binary Call Format (BCF) files.
• Efficient Computation on Compressed Data: Enables direct computation on compressed datasets without requiring decompression.
• Performance Improvements: Demonstrates loading times 8× faster, homozygosity computation 5× faster, dot products 30× faster, and allele counts 280× faster versus traditional methods.
• Integrated Compression-Compute File Format: Uses a novel file format that integrates compression with computational functionality to support in-place analyses.

Scientific Applications:

• Compressive Genomics: Supports large-scale genomic studies and biobank-scale analyses, including datasets such as the UK Biobank.
• Whole-Genome Sequencing (WGS): Facilitates storage and analysis workflows for high-throughput WGS genotype data.

Methodology:

Implements a novel file format that integrates compression with computational operations to enable direct computation on compressed genotype data.