XTalkDB

XTalkDB curates literature-derived molecular crosstalk between specific pairs of signaling pathways, consolidating evidence from over 1,600 publications covering 650 distinct pathway interactions.

Key Features:

• Comprehensive Crosstalk Data: Manually curates molecular crosstalk between signaling pathways and records specific molecular components such as proteins, hormones, and microRNAs that mediate interactions.
• Species and Tissue Specificity: Documents the species and tissue contexts in which each pathway crosstalk instance is observed.
• Literature Coverage: Aggregates evidence from over 1,600 publications encompassing 650 distinct pathway interactions.

Scientific Applications:

• Pathway Analysis: Enables investigation of how signaling pathways interact at a molecular level to inform studies of biological processes and disease mechanisms.
• Drug Discovery and Development: Provides curated crosstalk points that can inform therapeutic targeting of pathway interactions.
• Comparative Biology Studies: Supports comparative analyses across species using species-specific crosstalk annotations.

Methodology:

Systematic manual literature curation by reviewing over 1,600 publications to extract and record curated information on pathway crosstalk.