Yeast KID

Yeast KID aggregates and quantitatively integrates high-throughput and low-throughput phosphorylation experimental data from yeast to support identification and evaluation of kinase-substrate relationships.

Key Features:

• Database name: Also known as the Yeast Kinase Interaction Database (KID).
• Data integration: Integrates high-throughput and low-throughput experimental phosphorylation data from yeast systems.
• Experimental scope: Contains data from over 35,000 experiments, including 6,225 low-throughput interactions and 21,990 high-throughput interactions.
• Quantitative integration: Applies quantitative integration of diverse datasets to identify high-confidence kinase-substrate pairs.
• Gold standard: Establishes a gold standard comprising 517 high-confidence kinase-substrate pairs.
• Scope of interactions: Provides a comprehensive repository of phosphorylation-related interactions focused on yeast kinases and substrates.

Scientific Applications:

• Dataset evaluation: Enables evaluation of published high-throughput phosphorylation datasets using the 517-pair gold standard as a reference.
• Benchmarking: Serves as a benchmark for assessing the quality and accuracy of new high-throughput phosphorylation experiments.
• Signaling research: Supports analysis aimed at advancing understanding of signaling pathways and cellular processes governed by phosphorylation in yeast.

Methodology:

Quantitative integration of diverse high-throughput and low-throughput phosphorylation experimental datasets.