IMGT GeneInfo

IMGT GeneInfo provides detailed information on T cell receptor (TR) V(D)J recombinations for human and mouse, aggregating genomic and expressed repertoire data and annotations for TRA, TRB, TRG, and TRD loci to support analysis of adaptive immune repertoire diversity.

Key Features:

• Comprehensive rearrangement visualization: Visualizes rearrangement parameters for V-J and V-D-J recombinations across human and mouse TRA, TRB, TRG, and TRD loci.
• Integrated IMGT knowledge base: Integrates genomic and expressed repertoire data from the IMGT information system to link gene, sequence, and repertoire annotations.
• Standardized nomenclature and ontology: Implements IMGT-ONTOLOGY with standardized keywords, labels, nomenclature, unique numbering, and Colliers de Perles.
• Quality control and expanded repertoire data: Applies quality control procedures to data and provides over 59,000 rearrangement combinations with full gene descriptions.
• V(D)J gene use modeling and prediction: Models V(D)J gene usage and predicts recombination profiles, including non-standard profiles that may occur in pathological conditions.

Scientific Applications:

• Adaptive immune repertoire analysis: Enables analysis of T cell receptor diversity and V(D)J rearrangement patterns in human and mouse repertoires.
• Clinical mutation analysis: Supports mutation and rearrangement analysis in clinical contexts such as leukemia and lymphoma.
• Antibody engineering and humanization: Provides gene and rearrangement data relevant to antibody engineering, humanization, and design of therapeutic antibodies and fusion proteins.
• Comparative immunogenetics: Facilitates comparative studies of TR loci between human and mouse for basic, veterinary, and medical research.

Methodology:

Leverages IMGT-ONTOLOGY concepts to bridge genes, sequences, and 3D structures, and models V(D)J gene use to predict recombination profiles.